Molecular Interactions and Release Mechanisms of Finasteride in Beta-Cyclodextrin and Trimethyl-Beta-Cyclodextrin Complexes: A Computational and Experimental Approach

    October 2025 in “ Carbohydrate Polymer Technologies and Applications ”
    Reza Allahyari, Mehrdad Hadadian, Behnam Mahdavi
    TLDR TM-β-CD improves finasteride's solubility and delivery, while β-CD offers better long-term release.
    This study explores the encapsulation of finasteride (Fin) with β-cyclodextrin (β-CD) and trimethyl-β-cyclodextrin (TM-β-CD) to enhance its solubility and reduce side effects. TM-β-CD significantly improves Fin's solubility and bioavailability, making it a promising candidate for drug delivery, while β-CD offers better thermal stability and sustained release, suitable for long-term treatments. The research employs various characterization techniques and computational studies, revealing that TM-β-CD/Fin complexes release 95.27% of Fin within 72 hours, whereas β-CD/Fin complexes show a more sustained release. The study suggests these complexes could improve Fin's delivery and efficacy, recommending further in vivo studies to evaluate toxicity and bioavailability.
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