Molecular Interactions and Release Mechanisms of Finasteride in Beta-Cyclodextrin and Trimethyl-Beta-Cyclodextrin Complexes: A Computational and Experimental Approach

    October 2025 in “ Carbohydrate Polymer Technologies and Applications ”
    Reza Allahyari, Mehrdad Hadadian, Behnam Mahdavi
    Studysummary This study investigated improving Finasteride's water solubility using trimethyl-β-cyclodextrin (TM-β-CD) and β-cyclodextrin (β-CD) as carriers, finding that β-CD improved Fin's cumulative release, while TM-β-CD enhanced its solubility, with computational data supporting these outcomes.
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    4. Topical Finasteride Dose Evaluation for Treatment of Androgenetic Alopecia Using Computer Simulations Annales pharmaceutiques françaises · 2021
    5. Physicochemical Characterization of Finasteride Nanosystem for Enhanced Topical Delivery International Journal of Nanomedicine · 2021
    6. Encapsulation of Finasteride with Native and Modified Gamma-Cyclodextrins: Extensive Characterization of the Complexes International Journal of Pharmaceutics · 2020
    7. Enhancement of Dermal Delivery of Finasteride Using Microemulsion Systems Advanced Pharmaceutical Bulletin · 2019
    8. Applications of Steroid Drugs Entrapped in Cyclodextrins Environmental Chemistry Letters · 2019
    9. Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins Drug Design Development and Therapy · 2017
    10. Androgenetic Alopecia: A Review Endocrine · 2017
    11. Binary and Ternary Inclusion Complexes of Finasteride in HPβCD and Polymers: Preparation and Characterization Bioorganic & Medicinal Chemistry · 2009
    12. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009

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