Anti-Alopecia Activity of Coumarin Derivatives from Merremia Peltata Leaves and Their Binding to Androgen Receptors: A Molecular Study

The document presents a study on the anti-alopecia activity of two coumarin derivatives, scopolin and scopoletin, isolated from the leaves of the Indonesian plant Merremia peltata. Using molecular docking and molecular dynamics simulations, the compounds were found to have comparable binding energy to the androgen receptor, a key player in hair loss, but lower than the standard drug finasteride. In vivo tests on male rabbits showed that areas treated with a 30% concentration of scopolin and scopoletin had higher hair growth rates than those treated with 2% minoxidil, a common hair growth stimulant. The study concludes that scopolin and scopoletin could potentially be used as treatments for hair loss, but further research is needed to confirm their effectiveness and safety.