Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Merremia Peltata as a Potential Anti-Alopecia Treatment

    January 2021 in “ Journal of advanced pharmaceutical technology & research ”
    Syawal Abdurrahman, Ruslin Ruslin, Aliya Nur Hasanah, Resmi Mustarichie
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    TLDR The compound 16 from the Merremia peltata plant could potentially be a good treatment for hair loss (alopecia) due to its strong activity and favorable skin absorption.
    This study explored the potential of compounds from the Merremia peltata plant as a treatment for alopecia. Through molecular docking and ADME-Tox prediction, the researchers found that compound 16 (olean-12-en-3beta-ol, cinnamate) exhibited strong bond energy and superior activity compared to commonly used alopecia treatments. ADME-Tox prediction also indicated favorable results for compound 16 in terms of skin permeability, absorption, and distribution. These findings suggest that compound 16 could potentially serve as an androgen receptor antagonist and be beneficial in treating alopecia.
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