Development and Characterization of Poly(Lactic-Co-Glycolic Acid) Nanoparticles With Finasteride and In Vivo Evaluation of Their Efficacy in Hair Growth

    Lara Soares Junqueira, Mariana Sato de Souza Bustamante Monteiro, Lúcio Mendes Cabral
    TLDR Finasteride-loaded nanoparticles were successfully created for potential improved hair growth treatment.
    In the study, poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating finasteride were developed to enhance the drug's efficiency and minimize its systemic side effects for treating alopecia. Nanoparticles were produced with varying concentrations of finasteride (0, 10, 20, and 30mg). The reaction yields for these nanoparticles were 91.8% for drug-free, 82.6% for 10mg, 92.9% for 20mg, and 89.3% for 30mg. The average diameters were 162.2nm (drug-free), 176.1nm (10mg), 179.6nm (20mg), and 187.7nm (30mg). Encapsulation efficiency was 48.2% for 10mg, 90.7% for 20mg, and 83.2% for 30mg of finasteride. The study concluded that the development and encapsulation of finasteride within the nanoparticles were successful. An in vivo study is planned to assess the efficacy of these nanoparticles in promoting hair growth when administered orally.
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