Epigallocatechin Gallate and Tannic Acid Based Formulations of Finasteride for Dermal Administration and Chemoembolization

    October 2020 in “ Journal of Pharmaceutical Sciences ”
    John E. Jackson, Veronika Schmitt
    Studysummary This study found that using gallate-containing formulations like EGCG or tannic acid increased the solubility and controlled release of finasteride in microspheres, enhancing its dermal penetration in pig skin by 10 to 50 times compared to a control.
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    Research cited in this study 6

    1. Development of Finasteride/PHBV@Polyvinyl Alcohol/Chitosan Reservoir-Type Microspheres as a Potential Embolic Agent: From In Vitro Evaluation to Animal Study Biomaterials Science · 2020
    2. Transdermal Film-Loaded Finasteride Microplates to Enhance Drug Skin Permeation: Two-Step Optimization Study European Journal of Pharmaceutical Sciences · 2016
    3. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    4. Development of a Doxazosin and Finasteride Transdermal System for Combination Therapy of Benign Prostatic Hyperplasia Journal of pharmaceutical sciences · 2013
    5. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    6. Lack of Effect of Topical Finasteride Suggests an Endocrine Role for Dihydrotestosterone Fertility and Sterility · 2000