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Research

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research Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.

478 citations , September 1996 in “Proceedings of the National Academy of Sciences”

This study found that overexpression of PTHrP in mice chondrocytes led to short-limbed dwarfism and delays in endochondral ossification, highlighting PTHrP's role in inhibiting chondrocyte differentiation.

research Targeted Inactivation of Gh/Tissue Transglutaminase II

288 citations , January 2001 in “Journal of Biological Chemistry”

In this study, the disruption of Gh/tissue transglutaminase in mice did not affect viability but reduced thymocyte viability and fibroblast adhesion, suggesting its role in cell stabilization and extracellular matrix interactions.

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations , July 2018 in “Antioxidants”

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.

research A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis

280 citations , January 2004 in “The EMBO Journal”

AGC2-1 protein is essential for root hair growth in Arabidopsis.

Postoperative Chemotherapy and Tamoxifen Compared with Tamoxifen Alone in the Treatment of Positive-Node Breast Cancer Patients Aged 50 Years and Older with Tumors Responsive to Tamoxifen: Results from the National Surgical Adjuvant Breast and Bowel Project B-16

research Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16.

279 citations , June 1990 in “Journal of Clinical Oncology”

The study found that for positive-node breast cancer patients aged 50 and older, adding chemotherapy to tamoxifen significantly improved disease-free survival compared to tamoxifen alone.

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Community Join

5 / 1000+ results

community Take dut, 2-3 years and forget

215 upvotes 1 week ago

Dutasteride is considered superior for hair regrowth compared to finasteride, with many users reporting significant improvements. Some users experience side effects, but many find dutasteride effective when combined with minoxidil and other treatments.

community Will taking hair loss orals affect trt?

5 upvotes 2 weeks ago

Taking finasteride or dutasteride with testosterone replacement therapy (TRT) can increase testosterone levels by blocking its conversion to DHT, potentially raising estrogen levels. Users suggest monitoring for high estrogen symptoms and possibly using an aromatase inhibitor like anastrozole if needed.

community Taking psyllium with oral minoxidil removed the heart palpitations

33 upvotes 2 weeks ago

Taking psyllium with oral minoxidil reduced heart palpitations but may also reduce the drug's effectiveness. Users suggest splitting the minoxidil dose or consulting a doctor for safer alternatives.

community I really don’t get the critique regarding taking Finasteride and Minoxidil everyday

in Chat 166 upvotes 1 month ago

Taking Finasteride and Minoxidil daily is compared to routine tasks, with some users emphasizing the benefits and minimal time commitment, while others express concerns about side effects, medication access, and dependency. Opinions vary on the importance of hair preservation versus potential risks, with some users willing to accept risks for better hair.

community Do the more newer gen topical retinoids e.g. tazarotene outperform tretinoin in inducing follicular sulfotransferase activity?

6 upvotes 1 month ago

Tazarotene may outperform tretinoin for hairline treatment with minoxidil, but lacks evidence. Tretinoin is recommended for the scalp, while tazarotene can be used on the face.

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Learn

7 / 45 results

learn tamsulosin

What is tamsulosin and how is it used in treatments related to hair loss? Tamsulosin is a prescription alpha-1 blocker approved for benign prostatic hyperplasia; no human trial has tested it for hair loss, and there are no dosing protocols or safety data for that use. Its connection to hair is a receptor-biology hypothesis, not a treatment.
Can tamsulosin affect hair growth when taken orally or applied topically? Tamsulosin does not significantly affect hair growth when taken orally or applied topically.
Is tamsulosin linked to hair thinning or hair improvement as a side effect? Published tamsulosin trials, the product label and regulatory reviews do not establish a link to hair thinning, and no controlled study supports it as a hair-growth treatment; scattered post-marketing reports of alopecia exist but are not evidence of cause.