Development and Ex-Vivo Skin Permeation Studies of Finasteride–Poly(Lactic Acid-Co-Glycolic Acid) and Minoxidil–Chitosan Nanoparticulate Systems

The study aimed to develop nanoparticulate systems for the controlled release of finasteride and minoxidil, two drugs commonly used for hair loss treatment. The nanoparticles were successfully prepared using nanoprecipitation and ionic gelation methods, and various variables were investigated. The study demonstrated the potential of nanoparticulate systems for the controlled release of hair loss drugs, with good stability and skin tolerance observed. Ex-vivo permeability studies revealed prolonged release of finasteride and minoxidil up to 24 hours, which can reduce the dosing frequency and improve patient compliance towards therapy. The study suggests that these nanoparticulate systems have potential as effective topical delivery systems for hair loss treatment.