Polymeric Nanohydrogel in Topical Drug Delivery System

March 2024 in “ International journal of nanomedicine ”

Nia Yuniarsih, Anis Yohana Chaerunisaa, Khaled M. Elamin, Nasrul Wathoni

polymeric nanohydrogel nanohydrogel topical drug delivery finasteride androgenetic alopecia biocompatibility bioavailability stimuli-responsive properties NH Propecia

Studysummary This review discusses recent advancements in the development and use of polymer-based nanohydrogels for topical drug delivery, noting their potential to enhance drug loading, release control, and skin penetration for treating dermatological conditions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the use of polymeric nanohydrogels (NH) in topical drug delivery systems. NH are viscoelastic, hydrophilic polymeric networks within the sub-micron size range, used as nanocarriers in drug delivery. They offer several advantages such as active ingredient protection, biocompatibility, versatile drug formulation, stimuli-responsive properties, and enhanced bioavailability. However, they also have potential drawbacks like tissue toxicity and severe polymerization reactions. NH have shown promise in various biomedical applications, including drug delivery systems, wound dressings, tissue engineering, and regenerative medicine. They have been used to deliver various drugs and natural compounds for the treatment of different conditions, including psoriasis, arthritis, melanoma, cutaneous leishmaniasis, rheumatoid arthritis inflammation, and skin cancer. Importantly, nanogel formulations of finasteride have been developed for the topical treatment of androgenetic alopecia, showing potential in the management of this condition. Despite the promising preclinical data, concerns related to toxicity, immunogenicity, and regulatory challenges need to be addressed for successful clinical translation.

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