A Novel Nanogel Formulation of Finasteride for Topical Treatment of Androgenetic Alopecia: Design, Characterization and In Vitro Evaluation

July 2021 in “ International Journal of Applied Pharmaceutics ”

Divya Sanganabhatla, R Shyam Sunder

finasteride nanogel androgenetic alopecia topical treatment solubility permeability biocompatibility gelling capacity viscosity stability drug content spreadability cumulative drug release Propecia

TLDR The finasteride nanogel could be an effective topical treatment for hair loss.

The study developed and evaluated a novel finasteride (FSD) nanogel for topical treatment of androgenetic alopecia. The nanogel formulation aimed to enhance solubility, permeability, and biocompatibility, addressing issues with oral delivery. The optimized nanogel (C2 batch) demonstrated excellent gelling capacity, clear appearance, good viscosity, and stability. It showed a high drug content (91.25±0.9%), effective spreadability (6.7 cm/sec), and significant cumulative drug release (758.52±1.49 µg at 24 h). The results indicated that the finasteride nanogel could be a promising topical treatment for androgenetic alopecia.

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Related Research

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