4 citations
,
July 2022 in “Clinical and Experimental Dermatology” This review examines the efficacy and safety of using minoxidil at concentrations greater than 5% for androgenetic alopecia but reports no new clinical results, emphasizing a need for further research.
14 citations
,
June 2021 in “Journal of dermatological science” This study found that Argan press cake extracts stimulated hair growth and reduced inflammation and oxidative stress in human hair follicle dermal papilla cells, suggesting potential for anti-hair loss drug development.
14 citations
,
April 2021 in “International journal of molecular sciences” This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.
17 citations
,
April 2021 in “Molecules/Molecules online/Molecules annual” This study found that linoleic acid from Malva verticillata seed extracts may promote hair follicle cell growth and counteract hair loss signaling in a lab setting.
15 citations
,
May 2020 in “BMC complementary medicine and therapies” This study found that Polygonum multiflorum extract may promote hair growth by increasing anagen duration and activating dermal papilla cells in human hair follicles, as observed in cultured cell models.
117 citations
,
August 2019 in “Drug Design Development and Therapy” This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.
13 citations
,
March 2019 in “Journal of Dermatological Treatment” This review explores the inconsistent therapeutic effects and side effects of finasteride for androgenic alopecia, highlighting the need for further research to better predict individual patient responses.
14 citations
,
September 2018 in “International Journal of Molecular Sciences” This study found that mackerel-derived fermented fish oil extract and its component DHA promote hair growth by activating anagen pathways in dermal papilla cells.
26 citations
,
August 2018 in “Dermatologic Therapy” This review discusses the research supporting the approval and use of minoxidil for androgenic alopecia and reports no new clinical results, emphasizing recent findings and developments.
76 citations
,
August 2018 in “International Journal of Cosmetic Science” This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.
13 citations
,
June 2018 in “Current Urology Reports” This review suggests that while finasteride for male pattern hair loss was previously considered safe, there is now evidence associating 5-α reductase inhibitors with significant sexual and reproductive side effects.
100 citations
,
September 2017 in “Molecular and Cellular Endocrinology” This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
153 citations
,
March 2017 in “Endocrine” This review examines recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia, highlighting two major genetic risk loci, but does not report new clinical findings.
36 citations
,
February 2017 in “BMC Complementary and Alternative Medicine” In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.
13 citations
,
December 2016 in “Journal of Cosmetic Dermatology” This study found increased oxidative stress in younger male patients with early-onset androgenetic alopecia compared to healthy peers, suggesting a potential role for antioxidants in their treatment.
47 citations
,
August 2016 in “Fitoterapia” This article reviews mechanisms by which herbal ingredients may stimulate or inhibit hair growth, and it reports no new clinical findings while suggesting potential for developing hair loss treatments.
29 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.
59 citations
,
November 2015 in “International Journal of Cosmetic Science” This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.
8 citations
,
October 2015 in “PubMed” Recent Phase III trials reported that once daily 5% minoxidil foam significantly increased hair count in women with female pattern hair loss and was shown to be as effective as twice daily 2% minoxidil solution.
20 citations
,
August 2015 in “International Journal of Molecular Medicine” This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.
3 citations
,
March 2015 in “Biomolecules & Therapeutics” In this study, BP201, derived from porcine lung phospholipids, promoted hair growth in mice, especially when combined with minoxidil, and increased hair follicle numbers and dermal papilla cell proliferation.
35 citations
,
December 2014 in “Clinical and experimental dermatology” This study found that patients with alopecia areata had reduced erythrocyte SOD and GSH-Px activities and elevated plasma MDA levels, suggesting a potential role of oxidative stress in the disease's pathogenesis.
17 citations
,
May 2014 in “Naunyn-Schmiedeberg's Archives of Pharmacology” In this study, 7-phloroeckol, derived from marine brown algae, was found to promote hair growth by increasing cell proliferation and hair shaft elongation in cultured human hair follicles.
39 citations
,
December 2013 in “Phytotherapy Research” This study found that hydroxysafflor yellow A-rich Carthamus tinctorius extract promoted hair growth and gene expression linked to hair proliferation in both cell cultures and mouse models.
22 citations
,
November 2013 in “Clinical and experimental dermatology (Print)” This study suggests that Ecklonia cava, particularly its component dioxinodehydroeckol, may promote hair growth by enhancing dermal papilla and outer root sheath cell activity in culture and mice models.
51 citations
,
July 2013 in “Bioorganic & Medicinal Chemistry Letters” This study found that compound 2 from Polygonum multiflorum significantly increased dermal papilla cell proliferation and hair-fiber length, suggesting potential as a therapeutic agent for alopecia.
62 citations
,
July 2013 in “American Journal of Clinical Dermatology” This study found that alopecia areata patients had higher oxidative stress and lipid peroxidation levels than healthy controls, suggesting potential involvement in the disease's pathogenesis.
25 citations
,
November 2012 in “Phytotherapy Research” In this study, oral administration of Crataegus pinnatifida extract was associated with hair growth promotion in mice by inducing anagen phase and enhancing cell signaling related to hair follicle development.
53 citations
,
October 2012 in “The FASEB Journal” This study found that bimatoprost stimulated hair growth in both human scalp follicle cultures and mouse pelage in vivo, suggesting it might offer a promising treatment for scalp alopecias.
88 citations
,
February 2011 in “Journal of Dermatological Science” This study found that topical minoxidil modestly extended the anagen phase in mice by activating β-catenin activity in dermal papilla cells.
321 citations
,
December 2009 in “Journal of Dermatological Science” This review discusses the role of dermal cells in hair follicle regeneration and morphogenesis and highlights their potential therapeutic implications, but it reports no new empirical findings.
217 citations
,
February 2009 in “The FASEB Journal” This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.
126 citations
,
January 2009 in “International Journal of Trichology” This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.
21 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” This review discusses a clinical approach to diagnosing alopecia through patient history and clinical findings, but it reports no new clinical results.
103 citations
,
April 2005 in “Experimental dermatology” This study found that PGF2alpha analogues and PGE2 stimulated hair follicle activity in mice, with PGF2alpha analogues also linked to potential side effects like poliosis when used as eye treatments.
49 citations
,
January 1998 in “International Journal of Molecular Medicine” In this study, lipid peroxides were found to induce apoptosis in hair follicle cells and advance the catagen phase in mice, suggesting a potential mechanism for alopecia development.
210 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the role of intrinsic skin signals, rather than serum signals, in regulating melanin synthesis and hair pigmentation, but reports no new experimental data.
