Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

    Jingoo Kang, Hoon-Seok Yoon, Sung Min Kim, Jeong Eon Park, Yu Jae Hyun, Ara Ko, Yong-Seok Ahn, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee‐Kyoung Kang
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    TLDR Mackerel-derived fermented fish oil helps hair grow by activating growth pathways and increasing cell proliferation.
    The document reports a study on the effects of mackerel-derived fermented fish oil (FFO) extract on hair growth, demonstrating that FFO extract and its component docosahexaenoic acid (DHA) promote hair growth by stimulating dermal papilla cell (DPC) proliferation and activating anagen-stimulating pathways. The study showed that FFO extract increased hair fiber length, initiated the anagen phase, and activated signaling pathways such as ERK, p38, and Akt, as well as causing nuclear translocation of ß-catenin. DHA also contributed to increased DPC proliferation and upregulated cell cycle-associated proteins. These findings suggest the potential of FFO extract and DHA as agents for hair growth promotion, although the number of subjects used in the study was not specified in the summary.
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