Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia

    Helen B. Everts, Kathleen A. Silva, Shalise Montgomery … John P. Sundberg
    Studysummary This study found that C57BL/6 mice with a diet containing specific levels of vitamin A showed alterations in retinoid metabolism and increased frequency of cicatricial alopecias, suggesting dietary factors may play a role in this condition.
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    Research cited in this study 10

    1. Endogenous Retinoids in the Hair Follicle and Sebaceous Gland Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2011
    2. Sebaceous Gland Loss and Inflammation in Scarring Alopecia: A Potential Role in Pathogenesis Journal of The American Academy of Dermatology · 2011
    3. Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans Veterinary pathology · 2010
    4. Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin Journal of biological chemistry/˜The œJournal of biological chemistry · 2008
    5. Etiology of Cicatricial Alopecias: A Basic Science Point of View Dermatologic therapy · 2008
    6. Management of Primary Cicatricial Alopecias: Options for Treatment British Journal of Dermatology · 2008
    7. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    8. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    9. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    10. Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias Archives of dermatology · 1999

    Related research 3

    1. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    2. Cutaneous Application of Alpha-Methylspermidine Activates the Growth of Resting Hair Follicles in Mice Amino Acids · 2009
    3. Melanogenesis During the Anagen-Catagen-Telogen Transformation of the Murine Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994