Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

    February 2009 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Michelle Shih, Maureen A. Kane, Ping Zhou, Chi Liang Eric Yen, Ryan S. Streeper, Joseph L. Napoli, Robert V. Farese
    TLDR DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.
    The study concluded that the enzyme DGAT1 was essential for retinoid homeostasis in murine skin by esterifying excess retinol to prevent toxicity. DGAT1 deficiency led to elevated retinoic acid (RA) levels, altered gene expression, disrupted hair cycling, and alopecia, which could be mitigated by a retinoid-deficient diet. These findings highlighted DGAT1's critical role in maintaining normal hair growth and skin health, suggesting potential implications for human skin and hair disorders treated with RA-modulating agents.
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