Etiology of Cicatricial Alopecias: A Basic Science Point of View

    July 2008 in “ Dermatologic therapy ”
    Kevin J. McElwee
    TLDR Cicatricial alopecia may be caused by immune attacks on hair follicles, gland issues, or stem cell damage.
    The document discussed the pathogenesis of cicatricial alopecia, highlighting several hypothetical mechanisms behind scarring alopecia. It suggested that targeted cytotoxic action against hair follicle cells, mediated by folliculocentric inflammation, might play a role. One hypothesis proposed autoimmune targeting of hair follicle-specific self-antigens, though this lacked direct evidence. Other theories included defects in sebaceous gland function, destruction of hair follicle stem cells, and disrupted communication between hair follicle mesenchyme and epithelium. The article emphasized the need for systematic research to address these hypotheses and advance the understanding of cicatricial alopecia etiology.
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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  98 upvotes 7 months ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

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