Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles
July 2002
in “
Journal of Investigative Dermatology
”
Research cited in this study
11 / 11 resultsresearch Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
Tcf3 and Lef1 are key in deciding skin stem cell roles.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
research A Unique Type I Keratin Intermediate Filament Gene Family is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles
research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia
The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.
research The Biology of Hair Follicles
Hair follicle biology advancements may lead to better hair growth disorder treatments.
research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias
Hair follicles grow hair and release it through the skin.
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The hr gene is crucial for skin and hair health, with mutations causing hair disorders.
research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development
EGFR is essential for normal hair development and follicle differentiation.
research Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.
research Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools
The "Handbook of Mouse Mutations with Skin and Hair Abnormalities" served as a comprehensive resource for understanding various genetic mutations in laboratory mice that affected skin and hair, providing valuable models for dermatological research. It covered a wide range of topics, including the biology of skin and hair in mice and humans, the use of inbred laboratory mice as models, and specific mutations affecting hair and skin, such as the hairless (hr) and rhino (hrrh) mutations on chromosome 14. The document also discussed the role of hair follicle stem cells, growth factors, and cytokine mutations in cutaneous pathology. Additionally, it explored the immune system's involvement in skin diseases and the search for mouse models of conditions like psoriasis. The handbook highlighted the importance of these models in studying genetic-based skin diseases and their potential applications in biomedical research.
research The Secret Life of the Hair Follicle
Hair follicles create different cell layers and proteins, controlled by various molecules.
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research Hair Disorders
The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.
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Only a few hair-specific keratins are linked to inherited hair disorders.
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Human hair follicles grown in vitro maintain normal keratin patterns and structure.
research Study on the distribution of hair keratin in normal hair follicles by immunohistochemical staining
The study investigated the distribution of the hair keratin family in normal scalp hair follicles using immunohistochemical staining. It found that different keratins were expressed in various parts of the hair follicle: RCK102 (K5, K8) in sebaceous and sweat glands, hair shaft, and root sheaths; LP1K (K7) in sebaceous and sweat glands and inner root sheath; RKSE60 (K10) in sebaceous gland; and RCK107 (K14) in the basal layer. The staining was more effective in cryosections and paraffin-embedded sections with antigen microwave restoration compared to simple paraffin-embedded sections. The study concluded that the varied distribution of hair keratin could help identify the origin of hair neoplasms.