Follicular Mucinosis: A Detailed Morphologic and Immunopathologic Study

    May 1984 in “ Journal of the American Academy of Dermatology ”
    Harold A. Lancer, Ben R. Bronstein, Hidemi Nakagawa, Atul K. Bhan, Martin C. Mihm
    TLDR Benign follicular mucinosis involves immune cells attacking hair follicles.
    Two patients with benign follicular mucinosis (FM) were studied using light and electron microscopy, direct immunofluorescence, and immunoperoxidase cell marker techniques. Light microscopy showed degenerative changes in the follicular outer root sheath and sebaceous gland epithelium, with benign inflammatory cells. Electron microscopy revealed close associations between disattached keratinocytes, macrophages, and Langerhans cells. Direct immunofluorescence highlighted complement (C3) and fibrinogen/fibrin in degenerated areas. Immunoperoxidase studies indicated an increase in T cells, macrophages, and Langerhans cells in the affected follicular epithelium, suggesting a role for cell-mediated immune mechanisms in the disease's pathogenesis.
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