The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

December 2016 in “ Journal of Cosmetic Dermatology ”

Hilal Kaya Erdoğan, Isil Bulur, Evin Kocatürk, Bahadir Yildiz, Zeynep Nurhan Saraçoğlu, Ozkan Alatas

oxidative stress early-onset androgenetic alopecia AGA antioxidants etiopathogenesis early-onset AGA

Studysummary This study found increased oxidative stress in younger male patients with early-onset androgenetic alopecia compared to healthy peers, suggesting a potential role for antioxidants in their treatment.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study investigated the role of oxidative stress in early-onset androgenetic alopecia (AGA) in male patients. The study found that there was increased oxidative stress in younger patients with early-onset AGA and that family history is associated with early-onset AGA. The authors suggest that further molecular and genetic studies are needed to investigate the relationship between oxidative stress and AGA etiopathogenesis. They also suggest that topical or systemic antioxidants could be promising in the future treatment of AGA.

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research The Impact of Oxidative Stress on Hair

59 citations , November 2015 in “International Journal of Cosmetic Science”

This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Is Early Onset Androgenic Alopecia a Marker of Metabolic Syndrome and Carotid Artery Atherosclerosis in Young Indian Male Patients?

24 citations , January 2015 in “International Journal of Trichology”

This research observed that among young men with androgenic alopecia, there was a significant association with metabolic syndrome compared to healthy controls, suggesting AGA as a potential early marker for metabolic risk.

research Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying

37 citations , October 2014 in “Maturitas”

This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.

Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

38 citations , November 2013 in “Journal of The American Academy of Dermatology”

This study found that higher BMI was significantly associated with more severe hair loss in men with male-pattern and early-onset androgenetic alopecia.

research Androgenetic Alopecia: An Update

88 citations , January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

This article reviews recent advancements in understanding and treating androgenetic alopecia, focusing on new genetic insights, stem cell roles, and diagnostic tools, without reporting new clinical results.

research The Investigation of Insulin Resistance and Metabolic Syndrome in Male Patients with Early-Onset Androgenetic Alopecia

42 citations , January 2011 in “European Journal of Dermatology”

In this study, higher scores of HOMA-IR and FIRI suggested that male patients with early-onset androgenetic alopecia may have insulin resistance, although no significant differences in metabolic syndrome were found compared to controls.

research Androgenic Alopecia: A Counterproductive Outcome of the Anabolic Effect of Androgens

11 citations , May 2009 in “Medical Hypotheses”

This paper proposes a theory explaining how the normal anabolic effects of androgens lead to structural changes and hair follicle miniaturization, contributing to androgenic alopecia.

research Oxidative Stress in Aging of Hair

126 citations , January 2009 in “International Journal of Trichology”

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated With p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations , August 2002 in “Experimental Gerontology”

This paper discusses key mechanisms of androgen metabolism in androgenetic alopecia and reports the effectiveness of treatments like oral finasteride and topical minoxidil, highlighting the limited success rate due to factors like follicular inflammation.

research Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

56 citations , June 2001 in “European journal of cardiovascular prevention & rehabilitation”

This study found that men with early-onset androgenic alopecia have a higher risk of needing coronary revascularization before age 60 compared to those with later onset or no hair loss.

research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

32 citations , August 1999 in “Journal of Investigative Dermatology”

This study found that individuals with early onset extensive androgenetic alopecia have an elevated ratio of DHT to testosterone, but no significant genetic linkage to markers on chromosomes 2 or 5 was detected.