The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

December 2016 in “ Journal of Cosmetic Dermatology ”

Hilal Kaya Erdoğan, Isil Bulur, Evin Kocatürk, Bahadir Yildiz, Zeynep Nurhan Saraçoğlu, Ozkan Alatas

oxidative stress early-onset androgenetic alopecia AGA antioxidants etiopathogenesis early-onset AGA

TLDR Oxidative stress increases in early hair loss, and family history plays a role; antioxidants may help future treatments.

This study investigated the role of oxidative stress in early-onset androgenetic alopecia (AGA) in male patients. The study found that there was increased oxidative stress in younger patients with early-onset AGA and that family history is associated with early-onset AGA. The authors suggest that further molecular and genetic studies are needed to investigate the relationship between oxidative stress and AGA etiopathogenesis. They also suggest that topical or systemic antioxidants could be promising in the future treatment of AGA.

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Research cited in this study

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research The Impact of Oxidative Stress on Hair

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research The Investigation of Insulin Resistance and Metabolic Syndrome in Male Patients with Early-Onset Androgenetic Alopecia

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research Androgenic Alopecia: A Counterproductive Outcome of the Anabolic Effect of Androgens

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research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

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research Molecular Mechanisms of Androgenetic Alopecia

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research Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

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research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

32 citations, August 1999 in “Journal of Investigative Dermatology”

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research The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

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