The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

December 2017 in “ Journal of Cosmetic Dermatology ”

Hilal Kaya Erdoğan, Isil Bulur, Evin Kocatürk, Bahadir Yildiz, Zeynep Nurhan Saraçoğlu, Ozkan Alatas

oxidative stress early-onset androgenetic alopecia AGA antioxidants etiopathogenesis early-onset AGA

TLDR Oxidative stress increases in early hair loss, and family history plays a role; antioxidants may help future treatments.

This study investigated the role of oxidative stress in early-onset androgenetic alopecia (AGA) in male patients. The study found that there was increased oxidative stress in younger patients with early-onset AGA and that family history is associated with early-onset AGA. The authors suggest that further molecular and genetic studies are needed to investigate the relationship between oxidative stress and AGA etiopathogenesis. They also suggest that topical or systemic antioxidants could be promising in the future treatment of AGA.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Cited in this study

13 / 13 results

research The Impact of Oxidative Stress on Hair

59 citations , November 2015 in “International Journal of Cosmetic Science”

Oxidative stress damages hair and contributes to aging, and managing it can help maintain hair health.

research Is Early Onset Androgenic Alopecia a Marker of Metabolic Syndrome and Carotid Artery Atherosclerosis in Young Indian Male Patients?

24 citations , October 2015 in “International Journal of Trichology”

Early balding in young Indian men may indicate a higher risk of metabolic syndrome and potential heart disease.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , May 2015 in “Journal of Investigative Dermatology”

Oxidative stress affects hair loss in men with androgenetic alopecia.

research Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying

37 citations , January 2015 in “Maturitas”

Men's hair loss is caused by hormones and genes, and can be treated with medication and surgery, while graying is due to aging and has no prevention except dyeing.

research Higher Body Mass Index Is Associated With Greater Severity of Alopecia in Men With Male-Pattern Androgenetic Alopecia in Taiwan: A Cross-Sectional Study

38 citations , February 2014 in “Journal of The American Academy of Dermatology”

Higher BMI links to worse hair loss in Taiwanese men.

research Androgenetic Alopecia: An Update

88 citations , September 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Minoxidil and finasteride effectively treat hair loss.

research The Investigation of Insulin Resistance and Metabolic Syndrome in Male Patients with Early-Onset Androgenetic Alopecia

42 citations , April 2011 in “European Journal of Dermatology”

Early balding men may have insulin resistance, but lifestyle changes can help.

research Androgenic Alopecia: A Counterproductive Outcome of the Anabolic Effect of Androgens

11 citations , September 2009 in “Medical Hypotheses”

Male pattern baldness is an unintended side effect of the body's use of androgens for muscle growth, especially in those genetically prone to it.

research Oxidative Stress in Aging of Hair

126 citations , January 2009 in “International Journal of Trichology”

Oxidative stress contributes to hair graying and loss as we age.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations , August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

research Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

56 citations , June 2001 in “European journal of cardiovascular prevention & rehabilitation”

Early balding linked to higher heart disease risk.

research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

32 citations , August 1999 in “Journal of Investigative Dermatology”

Early onset hair loss linked to genetics and androgen levels.

1 / 1 results

research The Role of Oxidative Stress in Early-Onset Androgenetic Alopecia

13 citations , December 2017 in “Journal of Cosmetic Dermatology”

Oxidative stress increases in early hair loss, and family history plays a role; antioxidants may help future treatments.