Sulforaphane-Rich Broccoli Sprout Extract Promotes Hair Regrowth in an Androgenetic Alopecia Mouse Model via Enhanced Dihydrotestosterone Metabolism

    Laxman Subedi, Duc Dat Le, Eunbin Kim, Subash Phuyal, Arjun Dhwoj Bamjan, Vinhquang Truong, Nam Ah Kim, Jung‐Hyun Shim, Jong Bae Seo, Suk-Jin Oh, Mina Lee, Jin Woo Park
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    TLDR Broccoli sprout extract may help regrow hair by improving hormone metabolism.
    The study explores the effects of sulforaphane-rich broccoli sprout extract (BSE) on hair regrowth in a mouse model of androgenetic alopecia (AGA). BSE was found to enhance dihydrotestosterone (DHT) metabolism, a key factor in AGA, and promote hair regrowth by accelerating the telogen-to-anagen transition and increasing hair follicle length and weight. In vivo experiments showed that BSE, particularly at a 20 mg/kg dose, achieved hair regrowth comparable to finasteride and superior to minoxidil. BSE also reduced plasma testosterone and DHT levels, suggesting dual anti-androgenic effects, and activated the Wnt/β-catenin signaling pathway. The study highlights BSE's potential as a natural therapeutic agent for AGA, with improved safety and efficacy profiles compared to current treatments, although further clinical investigations are needed to evaluate its efficacy and safety in humans.
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