Peptide CyRL-QN15 Accelerates Hair Regeneration in Diabetic Mice Through Binding to the Frizzled-7 Receptor

The study demonstrates that the peptide CyRL-QN15 significantly promotes hair regeneration in diabetic mice by interacting with the Frizzled-7 receptor and enhancing the Wnt/β-catenin signaling pathway. Using 80 mice, the research shows that CyRL-QN15 accelerates hair follicle stem cell (HFSC) activity, leading to increased hair growth and wound healing, particularly in diabetic conditions. The peptide outperformed minoxidil in both injured and non-injured models, achieving a 92.4% wound closure rate in diabetic KM mice with burns. While CyRL-QN15 effectively enhances hair regeneration, it does not aid in sweat gland regeneration, indicating its specific action on hair follicles. These findings suggest CyRL-QN15 as a promising therapeutic agent for hair regeneration in diabetic patients, though further research is needed to address species differences and pathway complexities.