The Role of EAAT4 in Epidermal Differentiation and Calcium Homeostasis During Aging

December 2023 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Johannes Bischof, Germina Rosenova, Vitus Woldrich, Maria Karolin Streubel, Klaus Richter, Albert Duranton, Mark Rinnerthaler

EAAT4 epidermal differentiation calcium homeostasis SLC1A6 keratinocyte differentiation skin barrier function loricrin filaggrin

TLDR EAAT4 decreases with age, harming skin function and calcium balance.

The study investigates the role of EAAT4 in epidermal differentiation and calcium homeostasis during aging. It was found that the expression of the EAAT4 gene (SLC1A6) significantly decreases with age, leading to an altered calcium gradient in the epidermis. This downregulation affects keratinocyte differentiation and skin barrier function. Experiments using skin explants and reconstructed human epidermis models showed that inhibiting EAAT4 disrupts the calcium gradient and reduces the expression of differentiation markers like loricrin and filaggrin. The findings suggest that EAAT4 is crucial for maintaining calcium homeostasis and proper skin function, and its decline with age contributes to the impaired skin barrier observed in older individuals.

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