Glutamic Acid Promotes Hair Growth in Mice

The study investigated the effects of glutamic acid (GA) on hair growth, using in vivo, ex vivo, and in silico models, including human keratinocyte cultures and topical application on mice. It was found that GA promotes hair growth and keratinocyte proliferation, increases cell viability, and decreases the expression of apoptotic genes in the skin. An excitotoxic concentration of GA was identified at 100 mM for keratinocytes. The study also revealed that GA receptors may interact with hair cycle genes, indicating a potential new skin signaling pathway. These results suggest that GA could be used pharmacologically and nutritionally to treat skin diseases and enhance hair growth. The study involved 5-6 mice per group and topical application of GA was performed once daily for 14 days. Further research is needed to explore the connection between skin disorders and GA, as well as the impact of dietary GA on skin health.