Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase

    December 2017 in “ International Journal of Molecular Sciences ”
    Soohwan Yum, Seongkeun Jeong, Do Hoon Kim, Sun-Young Lee, Wooseong Kim, Jin-Wook Yoo, Jung-Ae Kim, Oh Joon Kwon, Dae-Duk Kim, Do Sik Min, Yunjin Jung
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    TLDR Minoxidil boosts hair growth by increasing blood flow and nutrients to hair follicles.
    The study found that minoxidil, a drug used to treat hair loss, induces the production of vascular endothelial growth factor (VEGF) by inhibiting HIF-prolyl hydroxylase, which leads to increased blood flow and nutrient supply to hair follicles, promoting hair growth. The study suggests that this mechanism of action may explain why minoxidil is effective in promoting hair growth.
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