Minoxidil Reverses Androgen-Induced Inhibition of Endothelial Cell Migration Promoted by Dermal Papilla Cell Spheroids

This study explores the role of minoxidil in counteracting androgen-induced inhibition of angiogenesis, a process crucial for hair growth, particularly in androgenetic alopecia (AGA). The research found that dihydrotestosterone (DHT) reduces the expression of key angiogenic factors VEGF and FGF-2 in dermal papilla cell (DPC) spheroids, impairing their ability to promote endothelial cell migration. However, minoxidil was able to restore this migratory capacity without affecting VEGF or FGF-2 levels, suggesting it enhances angiogenic function through alternative mechanisms. These findings highlight minoxidil's potential therapeutic role in AGA by supporting the vascular environment necessary for hair follicle activity.