The Novel Excipient, Dodecyl-2-N, N-Dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin

January 2012 in “ Hair therapy & transplantation ”

Salma Debar, Susan Meier-Davis, Richard Martin, Bassam B. Damaj

dodecyl-2-N, N-dimethylaminopropionate hydrochloride DDAIP-HCl minoxidil male pattern hair loss skin absorption LC-MS/MS Rogaine

Studysummary This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study from 2012 examined the impact of dodecyl-2-N, N-dimethylaminopropionate hydrochloride (DDAIP-HCl) on the skin absorption of minoxidil, a common treatment for male pattern hair loss. It compared two formulations containing 0.05% and 0.5% DDAIP-HCl with a standard 5% minoxidil solution. The results indicated that 0.05% DDAIP-HCl increased minoxidil permeation by 5.7 times, while 0.5% DDAIP-HCl increased it by 116 times compared to the standard solution. Additionally, minoxidil concentration in the skin was 4.2 times higher with 0.05% DDAIP-HCl and 7 times higher with 0.5% DDAIP-HCl. This suggests that DDAIP-HCl significantly improves minoxidil delivery into the skin, which may enhance its effectiveness for treating hair loss. The study utilized human cadaver skin and measured minoxidil concentrations using LC-MS/MS.

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Research cited in this study

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research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

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research Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery

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A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

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research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

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research Minoxidil: Mechanisms of Action on Hair Growth

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research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

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research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.

research Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion

33 citations , June 1995 in “Journal of Pharmaceutical Sciences”

This study found that minoxidil penetration through the skin increased with higher ethanol content and occlusion, with the highest penetration observed at 90% ethanol.

research Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo

82 citations , March 1992 in “Journal of Investigative Dermatology”

research The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats

53 citations , May 1990 in “Journal of Dermatology”

In this animal study, topical minoxidil shortened the telogen phase of hair growth cycles in rats, suggesting it may stimulate certain follicles to progress more rapidly to anagen.

research Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness

31 citations , January 1989 in “Clinical and Experimental Dermatology”

In this study, topical 2% minoxidil did not significantly improve hair density measures in men with male pattern baldness, although there was no deterioration, suggesting a potential prophylactic effect.

research Alterations in Scalp Blood Flow After the Epicutaneous Application of 3% Minoxidil and 0.1% Hexyl Nicotinate in Alopecia

25 citations , November 1987 in “British Journal of Dermatology”

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research Androgenetic Alopecia Treated With Topical Minoxidil

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research Topical Minoxidil in Early Androgenetic Alopecia

44 citations , March 1987 in “Journal of The American Academy of Dermatology”

This study found that both 2% and 3% topical minoxidil were more effective than placebo in promoting hair growth for men with male pattern baldness over 12 months.

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