The Novel Excipient, Dodecyl-2-N, N-Dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin

The study from 2012 examined the impact of dodecyl-2-N, N-dimethylaminopropionate hydrochloride (DDAIP-HCl) on the skin absorption of minoxidil, a common treatment for male pattern hair loss. It compared two formulations containing 0.05% and 0.5% DDAIP-HCl with a standard 5% minoxidil solution. The results indicated that 0.05% DDAIP-HCl increased minoxidil permeation by 5.7 times, while 0.5% DDAIP-HCl increased it by 116 times compared to the standard solution. Additionally, minoxidil concentration in the skin was 4.2 times higher with 0.05% DDAIP-HCl and 7 times higher with 0.5% DDAIP-HCl. This suggests that DDAIP-HCl significantly improves minoxidil delivery into the skin, which may enhance its effectiveness for treating hair loss. The study utilized human cadaver skin and measured minoxidil concentrations using LC-MS/MS.