The Novel Excipient, Dodecyl-2-N, N-Dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin

    January 2012 in “ Hair therapy & transplantation ”
    Salma Debar, Susan Meier-Davis, Richard Martin, Bassam B. Damaj
    Studysummary This study observed that DDAIP-HCl enhanced the permeation of minoxidil through human cadaver skin, suggesting potential for improved treatment efficacy in male pattern hair loss.
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    Research cited in this study 23

    1. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    2. Relation Between Treatment Efficacy and Cumulative Dose of 3% Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 2011
    3. Randomized Clinical Trial Comparing 5% and 1% Topical Minoxidil for the Treatment of Androgenetic Alopecia in Japanese Men Journal of Dermatology · 2009
    4. Formulation and In Vitro Assessment of Minoxidil Niosomes for Enhanced Skin Delivery International Journal of Pharmaceutics · 2009
    5. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    6. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    7. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    8. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    9. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    10. Penetration of Minoxidil from Ethanol/Propylene Glycol Solutions: Effect of Application Volume and Occlusion Journal of Pharmaceutical Sciences · 1995
    11. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    12. The Effect of Topical Minoxidil on Hair Follicular Cycles of Rats Journal of Dermatology · 1990
    13. Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness Clinical and Experimental Dermatology · 1989
    14. Alterations in Scalp Blood Flow After the Epicutaneous Application of 3% Minoxidil and 0.1% Hexyl Nicotinate in Alopecia British Journal of Dermatology · 1987
    15. Androgenetic Alopecia Treated With Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    16. Topical Minoxidil in Early Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    17. Action of Topical Minoxidil in the Bald Stump-Tailed Macaque Journal of The American Academy of Dermatology · 1987
    18. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    19. Long-Term Efficacy of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    20. Dose-Response Study of Topical Minoxidil in Male Pattern Alopecia Journal of The American Academy of Dermatology · 1987
    21. Dose-Response Study of Topical Minoxidil in Male Pattern Baldness Journal of The American Academy of Dermatology · 1986
    22. Review: Topical Minoxidil for Male Pattern Baldness The American Journal of the Medical Sciences · 1986
    23. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984

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    1. The Novel Excipient, Dodecyl-2-N, N-Dimethylaminopropionate Hydrochloride (DDAIP-HCl) Improves the Flux of Minoxidil in Human Skin Hair therapy & transplantation · 2012