Justicia Procumbens Prevents Hair Loss in Androgenic Alopecia Mice

December 2023

Dae‐Dong Kim, Eun-Young Lee, Pyeong Geun Choi, Hee Soo Kim, So-Hyun Park, Hyo‐Deok Seo, Jeong‐Hoon Hahm, Jiyun Ahn, Chang Hwa Jung

Justicia procumbens androgenic alopecia human hair follicle dermal papilla cells HFDPC testosterone-induced AGA Wnt/β-catenin signaling pathway cyclin D1 VEGF β-catenin AGA Wnt signaling vascular endothelial growth factor

Studysummary This study found that an extract from Justicia procumbens may prevent hair loss in a mouse model of androgenic alopecia by enhancing hair follicle cell proliferation and improving hair characteristics. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effects of an aqueous extract of Justicia procumbens (JPAE) on androgenic alopecia (AGA), a common hair loss condition. The research used human hair follicle dermal papilla cells (HFDPC) and a mouse model of testosterone-induced AGA. The results showed that JPAE treatment increased HFDPC proliferation by activating the Wnt/β-catenin signaling pathway, crucial for hair growth. It also increased the expression of Wnt targets, such as cyclin D1 and VEGF, by promoting the translocation of β-catenin to the nucleus. In the AGA mouse model, JPAE administration reduced hair loss, increased hair thickness, and enhanced hair shine. The study concluded that JPAE is potentially effective against androgenic alopecia.

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