Long-Term Effectiveness and Safety of Dutasteride Versus Finasteride in Patients With Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study

January 2022 in “ Annals of Dermatology ”

Gwang Seong Choi, Woo-Young Sim, Hoon Chul Kang, Chang Hun Huh, Yang Won Lee, Sumitra Shantakumar, Yu-Fan Ho, Eun-Jeong Oh, Mei Sheng Duh, Wendy Cheng, Priyanka Bobbili, Philippe Thompson-Leduc, Gary Ong

dutasteride finasteride male androgenic alopecia BASP classification Propecia

TLDR Dutasteride is more effective than finasteride for long-term hair growth in men with androgenic alopecia.

This study compared the long-term effectiveness and safety of dutasteride and finasteride in treating male androgenic alopecia (AGA) in 600 South Korean patients. Dutasteride-treated patients (n=295) showed significantly greater improvement in hair growth compared to finasteride-treated patients (n=305), with 80.8% of dutasteride users showing improvement in BASP classification versus 47.8% of finasteride users. Both treatments had similar safety profiles, with low rates of adverse events and treatment discontinuation. The study supports dutasteride's superior efficacy in long-term AGA treatment.

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Research cited in this study

21 / 21 results

Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia in Men and Women: A Systematic Review with Network Meta-Analyses and an Assessment of Evidence Quality

15 citations, April 2020 in “Journal of Dermatological Treatment”

Minoxidil and finasteride work best for hair loss; more research needed.

The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis

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Evaluation of Long-Term Efficacy of Finasteride in Korean Men with Androgenetic Alopecia Using the Basic and Specific Classification System

research Evaluation of Long-Term Efficacy of Finasteride in Korean Men with Androgenetic Alopecia Using the Basic and Specific Classification System

11 citations, December 2018 in “Journal of Dermatology”

Finasteride effectively treats hair loss in Korean men for at least 5 years, with V type responding better.

research Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version

36 citations, June 2018 in “Journal of Dermatology”

Use finasteride, dutasteride, and minoxidil for hair loss treatment.

Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-Analysis

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Finasteride and dutasteride increase sexual dysfunction risk by 1.57 times in male hair loss treatment.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations, November 2017 in “Journal of The European Academy of Dermatology and Venereology”

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research Long-Term Efficacy and Safety of the Dual 5-Alpha Reductase Blocker Dutasteride on Male Androgenetic Alopecia Patients

6 citations, December 2016 in “Journal of Dermatology”

Dutasteride effectively and safely treats male hair loss for over a year.

Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

research Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study

33 citations, August 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

Dutasteride is more effective than finasteride at increasing hair count and reversing hair thinning in men with hair loss, but both have similar side effects.

research Adverse Effects and Safety of 5-Alpha Reductase Inhibitors (Finasteride, Dutasteride): A Systematic Review

32 citations, July 2016 in “PubMed”

5-alpha reductase inhibitors are generally safe but can cause sexual side effects and require patient education on risks.

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Hair loss requires customized treatments based on its various causes and types.

research Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia

32 citations, February 2016 in “Journal of Dermatology”

Dutasteride safely promotes hair growth and reduces hair loss, with mild side effects.

research Safety and Tolerability of the Dual 5-Alpha Reductase Inhibitor Dutasteride in the Treatment of Androgenetic Alopecia

19 citations, January 2016 in “Annals of Dermatology”

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations, January 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research An Epidemiological Study of Androgenic Alopecia in 3114 Korean Patients

20 citations, December 2013 in “Clinical and Experimental Dermatology”

Smoking and drinking worsened hair loss in men with genetic hair loss, while eating and sleeping habits didn't; genetics played a bigger role than environment in hair loss.

research Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study

101 citations, January 2012 in “Annals of Dermatology”

Men with hair loss experience lower quality of life, worsened by factors like age, severity, and treatment history.

Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

research Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

92 citations, June 2010 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg daily improves hair growth safely in men with hair loss.

research A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification

125 citations, May 2007 in “Journal of The American Academy of Dermatology”

The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.

research Dutasteride Improves Male Pattern Hair Loss in a Randomized Study in Identical Twins

39 citations, March 2007 in “Journal of Cosmetic Dermatology”

Dutasteride helps slow hair loss and boosts hair growth.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations, November 2006 in “Journal of The American Academy of Dermatology”

Dutasteride more effective for hair growth, but has more side effects than finasteride.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

research Androgens and Alopecia

165 citations, December 2002 in “Molecular and Cellular Endocrinology”

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

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community AGA evaluation and first steps - BEGINNER MEGAPOST

in Chat 73 upvotes 2 months ago

The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

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Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

community Diffuse hair loss and scalp biopsies

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community New Dutasteride Long Term Study (5 years) it works.

in Finasteride/Dutasteride 106 upvotes 1 year ago

The conversation discusses a five-year study on dutasteride, a medication for male hair loss. The study found that 89.9% of patients saw improvement or prevention of hair loss progression, with varying success rates based on different balding patterns. Side effects were mostly sexual and decreased over time. Dutasteride was concluded to be a long-term, safe, and effective treatment for male hair loss.

community Why does it seem everyone favors finasteride over dutasteride?

in Female 62 upvotes 6 months ago

The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

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