Efficacy of Topical Minoxidil and Finasteride Association Compared to Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor-Blinded, 3-Arm, Pilot Trial

    October 2023 in “ Journal of Cosmetic Dermatology
    Alfredo Rossi, Gemma Caro
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    TLDR Using both minoxidil and finasteride together is more effective for hair growth than using either one alone in men with hair loss.
    The study involved 42 men with androgenetic alopecia (AGA) and examined the effectiveness of a combined treatment of 5% Minoxidil (MNX) and 0.25% topical Finasteride (F) compared to their individual use. Participants were divided into three groups: group A (19 men) used both MNX and F, group B (12 men) used F alone, and group C (11 men) used MNX alone. The results showed that all groups saw an increase in hair density, but the increase was only statistically significant in group A, suggesting that the combined treatment is more effective than using F alone. After 6 months, group A saw an increase of +81 hairs/cm2, significantly higher than group B (+18 hairs/cm2) and group C (+38 hairs/cm2). The combined treatment was also well-tolerated and had higher cosmetic acceptability. No significant differences were observed in hormonal levels between the groups. The study suggests that the combined treatment could be recommended for men with severe AGA or those unresponsive to other topical therapies.
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      community PP405 is nothing but a scam and Pelage know it.

      in Chat  78 upvotes 1 month ago
      PP405 is criticized for overhyped claims and cherry-picked data, with doubts about its effectiveness compared to minoxidil and finasteride. Many users express skepticism, emphasizing the need for more comprehensive trial results.

      community PP405 timeframe ? Could it replace current treatments ?

      in Update  36 upvotes 2 months ago
      PP405 is a potential new hair loss treatment that might replace finasteride and minoxidil, but it is still in clinical trials and may not be available until 2028-2031. There is skepticism about its effectiveness, with only a 20% increase in hair density observed in some participants.

      community Is there any hope for my hairline?

      in Treatment  12 upvotes 7 months ago
      The user experienced reduced hair fall with topical minoxidil and finasteride but no regrowth, and faced hormonal issues with oral finasteride. They are considering a hair transplant and exploring treatments like topical dutasteride, oral minoxidil, microneedling, and hair supplements.

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