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Glossary Collagen

protein providing structure and strength to connective tissues

Collagen is a protein that serves as a key structural component in various connective tissues, including skin, hair, nails, bones, and tendons. It provides strength and elasticity, helping to maintain the integrity and resilience of these tissues. As we age, collagen production decreases, which can lead to signs of aging such as wrinkles and weakened joints.

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Research

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Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that apocynin restored COL17A1 expression in human keratinocytes and reduced UVB-induced cellular senescence, DNA damage, and cell cycle arrest.

research Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell

8 citations , February 2020 in “Journal of Drug Delivery Science and Technology”

This study demonstrated that using PLGA nanoparticles to deliver chlorogenic acid significantly increased type 17 collagen production in human epidermal cells, indicating potential for improved skincare formulations.

research Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair

9 citations , January 2022 in “Theranostics”

This review discusses the role of collagen XVII in maintaining stem cell niches and its impact on skin aging and wound repair, without reporting new clinical results.

research Niche work when you can get it: collagen XVII and the melanocyte stem cell

2 citations , May 2011 in “Pigment Cell & Melanoma Research”

In this study, Tanimura et al. reported that loss of collagen XVII in mice leads to hair loss and pigmentation defects, potentially due to impaired TGF-beta signaling affecting melanocyte stem cell maintenance.

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Community Join

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community 17 month updateBefore & after pic.

in Progress Pictures 540 upvotes 1 year ago

The conversation discusses a user's impressive hair regrowth progress over 17 months using a topical minoxidil and finasteride spray from HIMS, with suggestions to add microneedling for better results. Some users express skepticism about the authenticity of the results, while others inquire about side effects and application methods.

community Male 17 - Thinning hair and crown

4 upvotes 7 years ago

A 17-year-old male is experiencing hair thinning, especially around the crown, and plans to use 5% minoxidil, a dermaroller or derma pen, Nizoral shampoo, and biotin shampoo. He is advised to consider finasteride in the future and is seeking affordable hair loss solutions.

community Starting on finasteride at 17.

in Finasteride/Dutasteride 6 upvotes 1 year ago

A 17-year-old is considering starting finasteride and minoxidil for hair loss, despite concerns about potential side effects and the impact on development. The user is advised to check if puberty is complete and to consider using only minoxidil until adulthood.

community 17M - beat the norwood reaper in 4 months. Am I a hyper responder? Can I maintain for a year until I can start fin?

in Progress Pictures 725 upvotes 1 year ago

A 17-year-old improved his hairline using minoxidil and derma stamping, planning to start finasteride at 18. He received advice on dosing and potential side effects to maintain results.

community 1 year on fin. No results. I give up.

in Finasteride/Dutasteride 43 upvotes 3 years ago

A user who has been taking finasteride, minoxidil, and microneedling for one year with no results, and the replies discuss other treatments, including dutasteride, which is feared due to potential side effects.

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