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Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

The protein Par3 is crucial for healthy skin, affecting the skin barrier, cell differentiation, and stem cell maintenance.

research KIF18B Is a Cell-Type Specific Regulator of Spindle Orientation in the Epidermis

June 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

KIF18B is important for correctly positioning cell division machinery in skin cells, affecting hair follicle development.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Early Inductive Events in Ectodermal Appendage Morphogenesis

160 citations , January 2014 in “Seminars in cell & developmental biology”

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

research A Matter of Life and Death: Self-Renewal in Stem Cells

150 citations , December 2012 in “EMBO Reports”

Stem cell self-renewal is complex and needs more research for full understanding.

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community Early Signs - Notes for diffuse thinners

in Treatment 10 upvotes 1 week ago

Diffuse thinning is often due to androgenetic alopecia, and DHT blockers like finasteride are recommended. Treatments mentioned include minoxidil, finasteride, dutasteride, and RU58841, with emphasis on starting early and using a holistic approach.

community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community Happily nuking my DHT and hairloss to oblivion.

in Finasteride/Dutasteride 79 upvotes 3 years ago

The effectiveness of Finasteride/Dutasteride for treating hair loss, and a cautionary tale about potential side effects such as gynecomastia.