Molecular Mechanisms of Asymmetric Divisions in Mammary Stem Cells

    November 2016 in “ EMBO Reports ”
    Angela Santoro, Thalia Vlachou, Manuel Carminati, Pier Giuseppe Pelicci, Marina Mapelli
    Studysummary This review evaluates methods to study stem cell division patterns, particularly in the mammary gland, and discusses genetic factors affecting division modalities and their implications for breast cancer, but reports no new results.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reviewed the molecular mechanisms of asymmetric cell divisions (ACDs) in mammary stem cells (MaSCs), emphasizing their role in tissue homeostasis and cancer. It highlighted the balance between asymmetric and symmetric cell divisions, with disruptions potentially leading to malignancy. The review drew parallels with Drosophila studies, noting challenges in translating findings to mammals. It explored the influence of proteins like the Par3/Par6/aPKC complex and signaling pathways such as Wnt and Notch on cell polarity and division orientation. The document underscored the complexity of MaSC regulation, the impact of genetic alterations on cancer development, and the potential for targeting ACD regulation as a therapeutic strategy in breast cancer.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results