Molecular Mechanisms of Asymmetric Divisions in Mammary Stem Cells
November 2016
in “
EMBO Reports
”
TLDR Disruptions in mammary stem cell division can lead to cancer, but targeting these processes might help treat breast cancer.
The document reviewed the molecular mechanisms of asymmetric cell divisions (ACDs) in mammary stem cells (MaSCs), emphasizing their role in tissue homeostasis and cancer. It highlighted the balance between asymmetric and symmetric cell divisions, with disruptions potentially leading to malignancy. The review drew parallels with Drosophila studies, noting challenges in translating findings to mammals. It explored the influence of proteins like the Par3/Par6/aPKC complex and signaling pathways such as Wnt and Notch on cell polarity and division orientation. The document underscored the complexity of MaSC regulation, the impact of genetic alterations on cancer development, and the potential for targeting ACD regulation as a therapeutic strategy in breast cancer.
