The Mechanical Forces That Shape Our Senses

March 2022 in “ Development ”

Anh Phuong Le, Jin Kim, Karl R. Koehler

hair placode hair follicles mechanical cues substrate stiffness cellular contractility organoids microphysiological systems

TLDR Mechanical forces are crucial in shaping our sensory organs during development.

The document reviewed how mechanical forces influenced the development of sensory organs, including hair placode formation in the skin. It emphasized the role of mechanical cues, such as substrate stiffness and cellular contractility, in patterning hair follicles and other sensory structures. The study of these forces was primarily conducted in model organisms, with human cell-based models like organoids showing promise for mimicking sensory organ development. The review highlighted challenges such as variability in organoid models and the need for comprehensive systems to understand the integration of mechanical and biochemical signals. It suggested that microphysiological systems could advance the study of sensory organ development and function.

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Research cited in this study

2 / 2 results

research Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

22 citations , May 2021 in “Nature Communications”

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

research Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

169 citations , January 2018 in “Cell Reports”

Scientists grew hair follicles from mouse stem cells in a lab setting.

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