TLDR Frizzled 3 and Frizzled 6 together control the orientation of mouse hair follicles.
The study demonstrated that Frizzled 3 (Fzd3) and Frizzled 6 (Fzd6) played redundant roles in controlling the planar cell polarity (PCP) of mouse hair follicles. The loss of either Fzd3 or Fzd6 alone did not significantly disrupt hair follicle orientation, but the combined loss led to noticeable defects, including vertically oriented hair follicles and a complete loss of anterior-posterior polarity. Fzd6 was found to be uniformly distributed in skin epithelial cells, and Cthrc1 was identified as a potential downstream effector enhancing Wnt/PCP signaling. These findings highlighted the importance of Fzd3 and Fzd6 in maintaining proper hair follicle orientation through PCP signaling pathways.
33 citations,
June 2017 in “Developmental Biology” Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.
114 citations,
January 2016 in “Current topics in developmental biology/Current Topics in Developmental Biology” Frizzled receptors are essential for various body development processes and maintaining certain body functions.
173 citations,
August 2015 in “Developmental cell” The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.
28 citations,
October 2014 in “Development” Fz3 and Fz6 can partially replace each other in tissue polarity and axon guidance.
29 citations,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
55 citations,
November 2010 in “Development” Hair follicles in mutant mice self-organize into ordered patterns within a week.
2 citations,
August 2023 in “Development” Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
55 citations,
November 2010 in “Development” Hair follicles in mutant mice self-organize into ordered patterns within a week.
29 citations,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Loss of Fz6 disrupts hair follicle and associated structures' orientation.
114 citations,
January 2016 in “Current topics in developmental biology/Current Topics in Developmental Biology” Frizzled receptors are essential for various body development processes and maintaining certain body functions.
72 citations,
April 2008 in “Organogenesis” Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.
