Functional Redundancy of Frizzled 3 and Frizzled 6 in Planar Cell Polarity Control of Mouse Hair Follicles

    January 2018 in “ Development ”
    Bo Dong, Samantha Vold, Cristina Olvera-Jaramillo, Hao Chang
    Studysummary This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.
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    Research cited in this study 9

    1. Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns Developmental Biology · 2017
    2. Frizzled Receptors in Development and Disease Current topics in developmental biology/Current Topics in Developmental Biology · 2016
    3. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    4. Partial Interchangeability of Fz3 and Fz6 in Tissue Polarity Signaling for Epithelial Orientation and Axon Growth and Guidance Development · 2014
    5. Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology Journal of Visualized Experiments · 2014
    6. Responses of Hair Follicle–Associated Structures to Loss of Planar Cell Polarity Signaling Proceedings of the National Academy of Sciences of the United States of America · 2013
    7. When Whorls Collide: The Development of Hair Patterns in Frizzled 6 Mutant Mice Development · 2010
    8. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009
    9. Exploiting the Keratin 17 Gene Promoter to Visualize Live Cells in Epithelial Appendages of Mice Molecular and Cellular Biology · 2005