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research Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development

7 citations , October 2022 in “Development”

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

research Functional redundancy of Frizzled 3 and Frizzled 6 in planar cell polarity control of mouse hair follicles

24 citations , January 2018 in “Development”

This study found that Frizzled genes Fzd3 and Fzd6 are redundantly involved in controlling hair follicle polarity in mice, but operate through distinct mechanisms, highlighting their complex role in hair orientation.

research Microcirculation-Promoting Effect of Escin on Cutaneous Tissue via Gsk3β Down-Regulation

1 citations , October 2025 in “Current Issues in Molecular Biology”

This research found that escin, when applied topically, enhances blood flow in human skin and promotes changes in endothelial cell signaling pathways, suggesting potential benefits for improving cutaneous microcirculation.

research Wnt signaling: the good and the bad

48 citations , July 2008 in “Acta Biochimica et Biophysica Sinica”

This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.

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community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 1 year ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

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Dermatologist
Dr. Nithya, MBBS, DDVL
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Bengaluru, Karnataka, India

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Dr. Nithya, MBBS, DDVL