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research Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development

7 citations , October 2022 in “Development”

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

research Region-specific reversal of epidermal planar polarity in the rosette fancy mouse

2 citations , August 2023 in “Development”

In this study, researchers explored how hair follicle orientation is affected in the rosette fancy mouse and found that a mutation in the PCP gene Fzd6 caused reversed hair orientations in the posterior region, leading to the formation of unique whorls.

research 851 The role of astrotactin2 in regulating mammalian skin polarity

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

This review discusses the similarities between wound healing and embryonic development, focusing on signaling pathways and their potential for developing new wound healing strategies, and reports no new clinical results.

research Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity

7 citations , January 2023 in “Frontiers in cell and developmental biology”

This study found that Celsr1, not Celsr2, is the primary protein involved in establishing planar cell polarity and hair follicle polarization in the epidermis of mice.

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community do any supplements actually work?

6 upvotes 2 years ago

A user asked if collagen or hair growth supplements made their hair thicker. Another user suggested that Vitamin D might help if deficient.

community TRUST THE PROCESS! Glad I stuck with it. Hope it gives more hope to others.

1987 upvotes 8 months ago

Significant hair regrowth was achieved after 8 months on oral finasteride (1mg) and 5 months on oral minoxidil (5mg) without side effects. The user stressed the importance of patience and consistency, despite initial shedding.

community is there anything that stops hair loss?

8 upvotes 1 year ago

A user is experiencing rapid hair loss and has been diagnosed with telogen effluvium by multiple dermatologists, but doubts the diagnosis due to the severity and speed of the hair loss. They are considering various treatments like spironolactone, estradiol, and possibly finasteride, while also exploring the possibility of hormonal imbalances or autoimmune issues.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

158 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community These posts about people taking everything at once and acting surprised never gets old

528 upvotes 5 months ago

People discuss hair loss treatments like minoxidil, finasteride, and dutasteride, sharing experiences and side effects. Opinions vary on combining treatments, with some skeptical and others reporting success.

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