Wnt Signaling in Skin Development, Homeostasis, and Disease

    Xinhong Lim, Roel Nusse
    TLDR Wnt signaling is crucial for skin development and health, and its disruption can cause skin diseases.
    The document reviewed the role of Wnt signaling in skin development, homeostasis, and disease, highlighting its importance in controlling the patterning of skin and influencing stem cell decisions in both embryonic and adult stages. Wnt signaling was identified as a key pathway in regulating the proliferation, differentiation, and function of skin cells and their appendages, such as hair and sebaceous glands. Disruptions in this pathway could lead to skin diseases, including cancers. The review aimed to consolidate established concepts and recent advances in understanding how Wnt signaling contributes to the dynamic regeneration and maintenance of skin integrity.
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