The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

December 2016 in “ PloS one ”

Mei Jin, Jing Wang, Mingxing Chu, Jinhua Piao, Junjie Piao, Fengqin Zhao

Keratin 26 secondary hair follicle hair growth hair development hair shaft inner root sheath cortex of skin hair follicles catagen phase telogen phase Melatonin Fibroblast Growth Factor 5 Insulin-like Growth Factor 1 MT FGF5 IGF-I

TLDR Keratin 26 affects cashmere goat hair growth and is influenced by various treatments.

The study conducted 7 years ago investigated the biological function of Keratin 26 in Liaoning Cashmere Goats. Keratin 26 was found to be expressed in the secondary hair follicle, suggesting its role in hair growth and development. It was also involved in the formation of hair shaft and inner root sheath. The study revealed that Keratin 26 was specifically expressed in the cortex of skin hair follicles, with greater expression in secondary follicles than primary ones during the catagen phase. The expression of Keratin 26 increased during the telogen phase. The study also found that Keratin 26 could inhibit cashmere growth and was related to the transition to catagen and telogen of hair follicles. Melatonin (MT), Fibroblast Growth Factor 5 (FGF5), and Insulin-like Growth Factor 1 (IGF-I) were found to affect the expression of Keratin 26, suggesting that Keratin 26 is a significant pathway that MT induces cashmere production in advance, FGF5 regulates cashmere growth, and IGF-I promotes cashmere growth and development.

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