Effect of the FA2H Gene on Cashmere Fineness of Jiangnan Cashmere Goats Based on Transcriptome Sequencing

July 2022 in “ BMC Genomics ”

Cuiling Wu, Jianying Li, Xinming Xu, Qi Xu, Chongkai Qin, Guifen Liu, Wei Chen, Guoping Zhang, Kechuan Tian, Xuefeng Fu

FA2H gene dermal papilla cells secondary hair follicles FGF5 BMP2 SOX18 SOX4 WNT5A

TLDR The FA2H gene improves cashmere fineness by enhancing hair growth in goats.

The study examined the impact of the FA2H gene on cashmere fineness in Jiangnan cashmere goats through transcriptome sequencing. Eight goats were divided into fine and coarse cashmere groups, revealing 479 differentially expressed genes. The FA2H gene was found to enhance the proliferation of dermal papilla cells in secondary hair follicles, influencing cashmere traits by regulating FGF5 and BMP2 gene expression. Overexpression of FA2H increased DPC activity and hair growth, indicating a positive correlation with cashmere fiber diameter. The study highlighted the potential of FA2H and other genes like SOX18, SOX4, and WNT5A in affecting cashmere fineness, providing valuable insights for improving cashmere quality through genetic and breeding strategies.

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