Comprehensive Analysis of circRNAs from Cashmere Goat Skin by Next Generation RNA Sequencing (RNA-seq)

    January 2020 in “ Scientific Reports ”
    Yuanyuan Zheng, Taiyu Hui, Yue Chang, Jiaming Sun, Dan Guo, Suling Guo, Suping Guo, Bojiang Li, Zeying Wang, Wenlin Bai
    TLDR Four circRNAs were found to be significantly different in cashmere goat skin, affecting cashmere fineness.
    The study conducted a comprehensive analysis of circular RNAs (circRNAs) in cashmere goat skin using next-generation RNA sequencing. Skin samples from Liaoning cashmere goats (LCG) and Inner Mongolia cashmere goats (MCG) were collected during the anagen period. The analysis identified 17 up-regulated and 15 down-regulated circRNAs in LCG compared to MCG. Further qPCR validation on 10 candidate circRNAs in coarse and fine type LCG skin confirmed significant differential expression of four circRNAs: ciRNA128, circRNA6854, circRNA4154, and circRNA3620. A bioinformatically deduced circRNAs-miRNAs regulatory network was proposed to help understand the molecular mechanisms of circRNA involvement in regulating cashmere fineness.
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