A Single-Cell Transcriptome Atlas During Cashmere Goat Hair Follicle Morphogenesis
January 2020
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
TLDR The research mapped out the cell types and molecular processes involved in developing Cashmere goat hair follicles.
In 2020, researchers conducted single-cell RNA sequencing on 19,705 single cells from various stages of fetus Cashmere goat dorsal skin to investigate the molecular profiles during Cashmere goat hair follicle development. The study identified 16 cell clusters and characterized their corresponding cell types. The research also revealed the molecular landscape along the dermal and epidermal cell lineage developmental pathways. Notably, a cross-species comparison with a murine model revealed conserved programs during dermal condensate fate commitment and discussed the heterochrony development of hair follicle development between mice and Cashmere goats. This study provided unparalleled molecular profiles of different cell populations during Cashmere goat hair follicle morphogenesis, offering a valuable resource for identifying biomarkers during Cashmere goat hair follicle development.
