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Glossary Dermal Condensate

cluster of specialized skin cells initiating hair follicle formation

Dermal condensate refers to a cluster of specialized cells in the skin's dermis layer that play a crucial role in the formation of hair follicles. These cells signal to the overlying epidermal cells to start the process of hair follicle development, making them essential for hair growth and regeneration.

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Research

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research Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates

2 citations , September 2023 in “PLoS biology”

This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.

research 872 Dermal Wnt/β-catenin signaling controls hair follicle dermal condensate size during development

April 2017 in “Journal of Investigative Dermatology”

This study suggests that dermal Wnt/β-catenin activation timing is crucial for hair follicle initiation, with potential non-cell autonomous regulation of dermal condensate size.

research Decision letter: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

April 2018

This study found that fibroblast growth factor 20 (Fgf20) orchestrates the movement and behavior of dermal fibroblasts, directing their formation into dermal condensates during hair follicle development in mice.

research Author response: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

1 citations , July 2018

In this study, Fgf20 was found to trigger movement and morphogenesis in dermal fibroblasts, facilitating dermal condensate formation essential for hair follicle development.

research 676 Wnt and SHH interact to determine hair follicle dermal condensate fate

July 2024 in “Journal of Investigative Dermatology”

Wnt and SHH signals together influence hair follicle cell development, offering insights for hair loss treatment.

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Community Join

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community 4 months update (fin + min + derma stamps)

in Progress Pictures 644 upvotes 1 year ago

The user shared a 4-month update on hair loss treatment using finasteride, minoxidil, and derma stamps, showing significant progress. The user experienced no side effects and plans to continue the treatment, updating monthly.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community How can I get this spot more filled in? (Before & After)

in Is this regrowth? 12 upvotes 1 year ago

The user has been using a daily topical spray of finasteride and minoxidil, along with occasional microneedling, to address hair loss since August 2023, and is considering switching to oral medication for convenience and cost reasons. Despite progress, they are exploring options like increasing microneedling frequency or potentially undergoing a hair transplant to address a stubborn spot.

community Indian Subcontinent specific : Fin effects

4 upvotes 6 years ago

Oral finasteride is recommended over topical finasteride for men in the Indian subcontinent, with no reported side effects. Minoxidil and dermarolling are also suggested, while dietary supplements and topical finasteride are deemed less effective.

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learn Stem Cell Factor

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