Rapid Mechanosensitive Migration and Dispersal of Newly Divided Mesenchymal Cells Aid Their Recruitment into Dermal Condensates

    September 2023 in “ PLoS biology ”
    Jon Riddell, Shahzeb Raja Noureen, Luigi Sedda … Denis J. Headon
    Studysummary This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.
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    Research cited in this study 9

    1. The Origins of Skin Diversity: Lessons From Dermal Fibroblasts Development · 2022
    2. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    3. Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves PLoS Biology · 2019
    4. Dermal Fibroblasts in Cutaneous Development and Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017
    5. Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis PLoS Biology · 2017
    6. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    7. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    8. Distinct Mechanisms Underlie Pattern Formation in the Skin and Skin Appendages Birth Defects Research · 2006
    9. The Secret Life of the Hair Follicle Trends in genetics · 1992