Melatonin Promotes the Development of Secondary Hair Follicles by Regulating circMPP5

April 2023 in “ Journal of Animal Science and Biotechnology ”

Xiaogao Diao, Lingyun Yao, Tao Duan, Jiaxin Qin, Liwen He, Wei Zhang

melatonin secondary hair follicles antioxidant levels anti-apoptotic protein apoptosis MAPK pathway circMPP5 miR-211 MAPK3 MT

Studysummary This study found that treating cashmere goat kids with melatonin significantly increased secondary hair follicle density, improving cashmere quality and yield, likely through mechanisms involving the MAPK signaling pathway. Our plain-language summary of this paper — not a Tressless recommendation.

The study "Melatonin promotes the development of the secondary hair follicles by regulating circMPP5" involved 32 newborn goats, half of which received melatonin (MT) treatment. The study found that MT treatment increased the density of secondary hair follicles, improving the yield and quality of cashmere without affecting the goats' live weight. This was achieved by increasing antioxidant levels, enhancing the expression of anti-apoptotic protein, and reducing apoptosis. The study also found that MT promotes the proliferation of secondary hair follicle cells at an early age through the regulation of the MAPK pathway via the circMPP5 sponging the miR-211, which regulates the expression of MAPK3. This process increases the numbers of secondary hair follicles, thus improving the production of cashmere from these goats.

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