Fibronectin Meshwork Controls Epithelial Stem Cell Fate

    May 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Soline Estrach, Lionel Tosello, Floriane S. Tissot … Chloé C. Féral

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that fibronectin is crucial for hair follicle stem cell function and regeneration, with its deletion impairing regeneration but restoration by dermal injection of exogenous fibronectin.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    2. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    3. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    4. CD98hc (SLC3A2) Regulation of Skin Homeostasis Wanes With Age ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine · 2013
    5. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    6. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    7. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    8. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    9. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    10. The Hair Cycle Journal of Cell Science · 2006
    11. The Hair Cycle Journal of Cell Science · 2006