Vitamin A Alleviates Heat Stress-Induced Damage to Hair Follicle Development in Rex Rabbits

October 2021 in “ Journal of the Science of Food and Agriculture ”

Zhengkai Yue, Chenyang Li, Yongxu Liu, Mengqi Liu, Man Zhao, Fuchang Li, Lei Liu

vitamin A hair follicle development heat stress Wnt10/β-catenin IGF1 FGF5 noggin-BMP SHH miR-205 miR-194 VA

TLDR Vitamin A improves fur quality in heat-stressed Rex rabbits.

The study investigated the effects of dietary vitamin A (VA) on hair follicle development in Rex rabbits under heat stress. Ninety rabbits were divided into three groups: a control group, a heat stress group, and a heat stress + VA group. The results showed that VA significantly increased hair follicle density, hair length, and the ratio of secondary to primary hair follicles in heat-stressed rabbits. VA also influenced the expression of several genes and signaling pathways, including Wnt10/β-catenin, IGF1, FGF5, noggin–BMP, and SHH, which are associated with hair follicle development. The study concluded that VA supplementation could improve fur quality in heat-stressed Rex rabbits by modulating these pathways.

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