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research Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

421 citations , January 2015 in “Chemical Society Reviews”

This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations , January 2004 in “Journal of Investigative Dermatology”

This study found that hair follicle characteristics vary significantly across different body sites, with the forehead and calf showing the highest potential follicular reservoirs, challenging previous assumptions about skin appendage distribution.

research Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.

294 citations , February 1994 in “PubMed”

This review highlights valproic acid's efficacy and tolerability as a first-line treatment for various seizure types in both adults and children, emphasizing its minimal neurological adverse effects compared to other antiepileptic drugs.

research Vaccines, adjuvants and autoimmunity

248 citations , August 2015 in “Pharmacological Research”

This review discusses case reports of autoimmune diseases following vaccination and the challenges of establishing a clear epidemiological connection, urging further investigation into vaccine-induced autoimmunity.

research Minoxidil upregulates the expression of vascular endothelial growth factor in human hair dermal papilla cells

192 citations , March 1998 in “British Journal of Dermatology”

This study found that minoxidil significantly increases VEGF mRNA and protein expression in dermal papilla cells, suggesting a role in enhancing hair follicle vascularization in androgenetic alopecia.

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community Vasodilators, Min, L-arginine, Niacin, Lisinoprol, etc.

in Minoxidil 4 upvotes 3 years ago

The conversation discusses the use of vasodilators like Minoxidil, L-arginine, and Niacin for hair regrowth, with Minoxidil causing intolerable side effects for the original poster. It also highlights that certain medications, including Lisinopril, antidepressants, and statins, can cause hair loss.

community Asi va mi resultado. Tratamiento con fin y min

in Progress Pictures 5 upvotes 1 month ago

The user shared progress pictures showing improvement in hair loss using oral finasteride and topical minoxidil. Another user suggested using dutasteride for better results.

community Any validity to this product being sold by a social media influencer?

in Product 1 year ago

The conversation is about skepticism towards a hair growth oil promoted by a social media influencer, with users suggesting it is ineffective without proven treatments like Minoxidil, finasteride, or hair transplants. The product contains various oils and extracts, but users doubt its effectiveness.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 1 year ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 2 years ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

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learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

What is valproic acid, and how did it become a subject of interest in hair growth and alopecia research? Valproic acid is a prescription anticonvulsant that laboratory and mouse studies link to the Wnt/β-catenin hair-growth pathway; one small randomized trial of an 8.3% topical spray reported a hair-count gain over 24 weeks. Oral valproate is also a recognized cause of hair loss and a known teratogen.
How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.
What biological mechanisms related to hair follicles are linked to valproic acid in experimental treatments? Valproic acid affects hair follicles by modulating cell signaling and gene regulation.
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