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Senescence-Associated Secretory Phenotype

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Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

1 citations, February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

research Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis

1 citations, March 2024 in “International journal of molecular sciences”

Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.

research Cellular Senescence in Tissue Repair: Every Cloud Has a Silver Lining

33 citations, January 2018 in “The International Journal of Developmental Biology”

Cell aging can be both good and bad for tissue repair.

research Minoxidil Regulates Aging-Like Phenotypes in Rat Cortical Astrocytes In Vitro

1 citations, December 2022 in “Biomolecules & therapeutics”

Minoxidil may help reduce aging effects in brain cells.

research Oncogenic Senescence: A Multi-Functional Perspective

32 citations, February 2017 in “Oncotarget”

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 743 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Pyrilutamide update: three months

in Update 32 upvotes 1 year ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 25 upvotes 1 year ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.