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GlossarySenescence-Associated Secretory Phenotype (SASP)

condition where aging cells release inflammatory molecules and enzymes

Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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research Cellular Senescence in Tissue Repair: Every Cloud Has a Silver Lining

33 citations, January 2018 in “The International Journal of Developmental Biology”

Cell aging can be both good and bad for tissue repair.

research Oncogenic Senescence: A Multi-Functional Perspective

32 citations, February 2017 in “Oncotarget”

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

research Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFkB and AP-1

1 citations, February 2023 in “International Journal of Molecular Sciences”

Melatonin improves cashmere goat hair quality by increasing follicles and reducing skin aging.

research Inducing Fate Changes at the Hair Follicle Stem Cell Niche

April 2023 in “Journal of Investigative Dermatology”

The study found that aging hair follicle stem cells change behavior, leading to hair loss, but drugs targeting these cells may help restore hair growth.

research Modeling the Onset of Senescence-Associated Secretory Phenotype Predicts Therapeutic Targets

April 2018 in “Journal of Investigative Dermatology”

The research found that blocking a gene called NEMO can potentially prevent harmful effects of aging at the cellular level.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 733 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Pyrilutamide update: three months

in Update 30 upvotes 2 years ago

A user's 3-month experience with pyrilutamide to reduce hair shedding, and how it may not be strong enough to stop the thinning of their hairline. Other users mentioned the effectiveness of minoxidil and finasteride for treating hair loss.

community Boys how is no one seeing positive results from pyrilutamide

in Chat 28 upvotes 2 years ago

Pyrilutimide, a treatment for hair loss; it's effectiveness compared to other treatments such as Finasteride and RU58841; and some users’ experiences with the treatment.