Melatonin Promotes Cashmere Goat (Capra Hircus) Secondary Hair Follicle Growth: A View from Integrated Analysis of Long Non-Coding and Coding RNAs

May 2018 in “ Cell Cycle ”

Wei Ge, Shan-He Wang, Bing Sun, Yuelang Zhang, Wei Shen, Hasan Khatib, Xin Wang

melatonin secondary hair follicle hair fiber growth goat secondary hair follicle stem cells gsHFSCs long non-coding RNAs lncRNAs mRNAs focal adhesion extracellular matrix receptor interaction vascular smooth muscle contraction stem cell pluripotency hair follicle morphogenesis hair follicle stem cells RNA ECM

TLDR Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

In the 2018 study on the effects of melatonin on secondary hair follicle growth in Cashmere goats, researchers found that melatonin at a concentration of 500 ng/L promoted hair fiber growth and proliferation of goat secondary hair follicle stem cells (gsHFSCs). High-throughput sequencing revealed differentially expressed long non-coding RNAs (lncRNAs) and mRNAs, indicating that melatonin affects genes involved in pathways crucial for hair follicle development, such as focal adhesion and extracellular matrix receptor interaction. Additionally, melatonin influenced lncRNAs targeting pathways related to vascular smooth muscle contraction and stem cell pluripotency. The study highlighted the regulatory roles of lncRNAs in hair follicle morphogenesis and the potential of melatonin in promoting hair growth. The number of samples or experimental replicates was not specified in the summary provided.

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