TLDR The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.
This study on Ordos fine-wool sheep used single-cell RNA sequencing to investigate the morphogenesis of secondary hair follicles, identifying 18 cell clusters and detailing the transcriptomic profiles of key cell types like dermal cells, fibroblasts, and epidermal cells. It highlighted the roles of signaling pathways such as Wnt, Hedgehog, Notch, and BMP in hair follicle development, and mapped differentiation trajectories for dermal and epidermal lineage cells. The research found that primary hair follicles mature earlier (E93) compared to secondary hair follicles (E110). The study provides insights into the molecular mechanisms of hair follicle development, which could aid in the molecular breeding of super-fine-wool sheep.
10 citations,
December 2021 in “Frontiers in cell and developmental biology” The research identified genes that explain why some sheep have curly wool and others have straight wool.
37 citations,
May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
29 citations,
January 2017 in “Journal of Investigative Dermatology” The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
56 citations,
August 1994 in “PubMed” Prolactin and melatonin can stimulate hair growth in Cashmere goat hair follicles, but melatonin may reduce follicle viability over time.
6 citations,
November 2022 in “Development” New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.
May 2020 in “Research Square (Research Square)” Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.
25 citations,
June 2022 in “Developmental cell” Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
December 2023 in “Animals” The study mapped yak skin cells to understand hair growth better.
3 citations,
November 2021 in “Frontiers in Genetics” Certain genes are linked to the quality of cashmere in goats.
