Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

December 2025 in “ Animals ”

Tong Xiao, Yuxia Luo, Chao Yuan, Yufang Song, Jianxiang Tang, Zengkui Lu, Jianbin Liu, Tingting Guo

TGFBR1 dermal papilla cells Wnt/β-catenin BMP Notch PCNA CCND1 CTNNB1 TGF-β signaling pathway hair follicle development TGF-beta Wnt signaling beta-catenin bone morphogenetic protein proliferating cell nuclear antigen cyclin D1 catenin beta-1

TLDR TGFBR1 slows down cell growth in fine-wool sheep hair follicles.

This study investigates the role of TGFBR1 in dermal papilla cells (DPCs) from fine-wool sheep, revealing that TGFBR1 acts as a negative regulator of DPC proliferation. Overexpression of TGFBR1 suppresses DPC proliferation, while its knockdown promotes it. The study highlights that TGFBR1 modulates multiple signaling pathways, including Wnt/β-catenin, BMP, and Notch, affecting the expression of key genes like PCNA, CCND1, and CTNNB1. These findings enhance the understanding of the TGF-β signaling pathway's role in hair follicle development and provide insights for molecular breeding in ultra-fine-wool sheep.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep

1 citations , January 2024 in “International journal of molecular sciences”

The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.

research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

February 2023 in “International Journal of Molecular Sciences”

Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.

research Androgens Downregulate BMP2, Impairing the Inductive Role of Dermal Papilla Cells on Hair Follicle Stem Cells Differentiation

6 citations , November 2020 in “Molecular and Cellular Endocrinology”

Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.

research All-Trans-Retinoic Acid Inhibits Mink Hair Follicle Growth by Inhibiting Proliferation and Inducing Apoptosis of Dermal Papilla Cells Through TGF-β2/Smad2/3 Pathway

10 citations , August 2020 in “Acta histochemica”

All-trans-retinoic acid stops mink hair growth by affecting cell growth and causing cell death.

research BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy

24 citations , September 2019 in “Experimental cell research”

BMP2 helps hair follicle stem cells become specialized by increasing PTEN, which causes autophagy.

research Early Inductive Events in Ectodermal Appendage Morphogenesis

160 citations , January 2014 in “Seminars in cell & developmental biology”

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

research Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations , April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations , June 2012 in “Genes & Development”

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling

25 citations , August 2010 in “Journal of Biological Chemistry”

Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.

research Disruption of Smad4 in Mouse Epidermis Leads to Depletion of Follicle Stem Cells

43 citations , December 2008 in “Molecular biology of the cell”

Disrupting Smad4 in mouse skin causes early hair follicle stem cell activity that leads to their eventual depletion.

research Smad4-Dependent Desmoglein-4 Expression Contributes to Hair Follicle Integrity

28 citations , July 2008 in “Developmental Biology”

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations , September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

Similar Research

5 / 387 results

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits

3 citations , March 2023 in “Biology”

Genes affecting wool fiber thickness in Angora rabbits were identified, which could help breed finer wool.

research Dermal Niche Signaling and Epidermal Stem Cells

January 2019 in “Advances in stem cells and their niches”

Skin health and repair depend on the signals between skin stem cells and their surrounding cells.

research The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss

November 2022 in “Life”

Natural products may help treat hair loss by promoting hair growth with fewer side effects.

research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

318 citations , January 2022 in “Signal Transduction and Targeted Therapy”

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.